Article
Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease.
The pharmacogenomics journal - 1 Dec 2014
Bank S, Andersen P S, Burisch J, Pedersen N, Roug S, Galsgaard J, Turino S Y, Brodersen J B, Rashid S, Rasmussen B K, Avlund S, Olesen T B, Hoffmann H J, Thomsen M K, Thomsen V Ø, Frydenberg M, Nexø B A, Sode J, Vogel U, Andersen V
Abstract excerpt
Antitumor necrosis factor-α (TNF-α) is used for treatment of severe cases of inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). However, one-third of the patients do not respond to the treatment. Genetic markers may predict individual response to anti-TNF therapy. Using a candidate gene approach, 39 mainly functional single nucleotide polymorphisms (SNPs) in 26 genes...
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