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Article

Genetic variations in the HIF1A gene modulate response to adjuvant chemotherapy after surgery in patients with colorectal cancer.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2014

Zhang Yi, Wang Peng, Zhou Xing-Chun, Bao Guo-Qiang, Lyu Zhuo-Ming, Liu Xiao-Nan, Wan Shao-Gui, He Xian-Li, Huang Qi-Chao

Abstract excerpt

BACKGROUND: Hypoxia-inducible factor 1α (HIF-1α) plays an important role in regulating cell survival and angiogenesis, which are critical for tumor growth and metastasis. Genetic variations of HIF1A have been shown to influence the susceptibility to many kinds of human tumors. Increased expression of HIF-1α has also been demonstrated to be involved in tumor progression. However, the prognostic value of single...

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PMID: 24969897
DOI: 10.7314/apjcp.2014.15.11.4637

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