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Article

Hecate/Grip2a acts to reorganize the cytoskeleton in the symmetry-breaking event of embryonic axis induction.

PLoS genetics - 1 Jun 2014

Ge Xiaoyan, Grotjahn Danielle, Welch Elaine, Lyman-Gingerich Jamie, Holguin Christiana, Dimitrova Eva, Abrams Elliot W, Gupta Tripti, Marlow Florence L, Yabe Taijiro, Adler Anna, Mullins Mary C, Pelegri Francisco

Abstract excerpt

Maternal homozygosity for three independent mutant hecate alleles results in embryos with reduced expression of dorsal organizer genes and defects in the formation of dorsoanterior structures. A positional cloning approach identified all hecate mutations as stop codons affecting the same gene, revealing that hecate encodes the Glutamate receptor interacting protein 2a (Grip2a), a protein containing multiple PDZ...

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PMID: 24967891
DOI: 10.1371/journal.pgen.1004422
PMCID: PMC4072529

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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