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Article

The WIRS motifs in Fat2 are required for Drosophila egg chamber rotation but not for elongation.

Development (Cambridge, England) - 15 Jan 2025

Bhatt Akanksha, Ruffine Valentin, Töpfer Uwe, Ryu Jinhee, Fischer-Friedrich Elisabeth, Dahmann Christian

Abstract excerpt

The elongation of tissues and organs is important for proper morphogenesis in animal development. In Drosophila ovaries, the elongation of egg chambers involves aligned Collagen IV fiber-like structures, a gradient of extracellular matrix stiffness and actin-based protrusion-driven collective cell migration, leading to the rotation of the egg chamber. Egg chamber elongation and rotation depend on the atypical...

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PMID: 39823598
DOI: 10.1242/dev.204201
PMCID: PMC11829772

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