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Article

Insights into the mechanism of CXCL12-mediated signaling in trophoblast functions and placental angiogenesis

19 Jul 2015

Abstract excerpt

The chemokine CXCL12 and its receptor CXCR4 are important signaling components required for human blastocyst implantation and the progression of pregnancy. Growing evidence indicates that the CXCL12/CXCR4 axis can regulate trophoblast function and uterine spiral artery remodeling, which plays a fundamental role in placentation and fetal outcome. The orphan receptor CXCR7 is also believed to partly regulate the...

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Share to Chemokine receptors and signaling
Share to Pregnancy and preeclampsia studies
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PMID: 26188201
DOI: 10.1093/abbs/gmv064

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