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Article

Cryptorchidism in the orl rat is associated with muscle patterning defects in the fetal gubernaculum and altered hormonal signaling.

Biology of reproduction - 1 Aug 2014

Barthold Julia S, Robbins Alan, Wang Yanping, Pugarelli Joan, Mateson Abigail, Anand-Ivell Ravinder, Ivell Richard, McCahan Suzanne M, Akins Robert E

Abstract excerpt

Cryptorchidism, or undescended testis, is a common male genital anomaly of unclear etiology. Hormonal stimulation of the developing fetal gubernaculum by testicular androgens and insulin-like 3 (INSL3) is required for testicular descent. In studies of the orl fetal rat, one of several reported strains with inherited cryptorchidism, we studied hormone levels, gene expression in intact and hormone-stimulated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle Development

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Share to Receptors, Androgen

Share to Receptors, G-Protein-Coupled

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Source

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Identifiers

PMID: 24966393
DOI: 10.1095/biolreprod.114.119560
PMCID: PMC4435416

Genes

INSL3
RXFP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cryptorchidism in the orl rat is associated with muscle patterning defects in the fetal gubernaculum and altered hormonal signaling.PMID 24966393Read ↗

Altered Expression of Muscle‐ and Cytoskeleton‐Related Genes in a Rat Strain With Inherited CryptorchidismSemantic proximity Read ↗

Polygenic inheritance of cryptorchidism susceptibility in the LE/orl rat.Semantic proximity Read ↗

Suppression of Insulin-Like3 Receptor Reveals the Role of β-Catenin and Notch Signaling in Gubernaculum DevelopmentSemantic proximity Read ↗

Targeted disruption of the Insl3 gene causes bilateral cryptorchidism.Semantic proximity Read ↗

INSL3/RXFP2 Signaling in Testicular DescentSemantic proximity Read ↗

The molecular basis of cryptorchidism.Semantic proximity Read ↗

Cryptorchidism in Mice with an Androgen Receptor Ablation in Gubernaculum TestisSemantic proximity Read ↗

Developmental Expression and Gene Regulation of Insulin-like 3 Receptor RXFP2 in Mouse Male Reproductive Organs1Semantic proximity Read ↗

Cryptorchidism in mice mutant for Insl3.Semantic proximity Read ↗

Cryptorchidism in LhrKO animals and the effect of testosterone-replacement therapy.Semantic proximity Read ↗

Insulin-Like 3 Exposure of the Fetal Rat Gubernaculum Modulates Expression of Genes Involved in Neural Pathways1Semantic proximity Read ↗

INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent.Semantic proximity Read ↗

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