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Suppression of transforming growth factor β signaling promotes ground state pluripotency from single blastomeres

24 Jun 2014

Abstract excerpt

STUDY QUESTION: Can transforming growth factor β (TGFβ) inhibition promote ground state pluripotency of embryonic stem cells (ESCs) from single blastomeres (SBs) of cleavage embryos in different mouse stains? SUMMARY ANSWER: Small molecule suppression of extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) and TGFβ signaling (designated as R2i) can enhance the generation of mouse ESCs from SBs of...

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PMID: 24963166
DOI: 10.1093/humrep/deu134

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