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Article

Association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and manual aiming control in healthy subjects.

PloS one - 1 Jan 2014

Lage Guilherme M, Miranda Débora M, Romano-Silva Marco A, Campos Simone B, Albuquerque Maicon R, Corrêa Humberto, Malloy-Diniz Leandro F

Abstract excerpt

BACKGROUND: Prefrontal dopamine is catabolized by the catechol-O-methyltransferase (COMT) enzyme. Current evidence suggests that the val/met single nucleotide polymorphism in the COMT gene can predict the efficiency of executive cognition in humans. Individuals carrying the val allele perform more poorly because less synaptic dopamine is available. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the influence of...

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Source

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Identifiers

PMID: 24956262
DOI: 10.1371/journal.pone.0099698
PMCID: PMC4067272

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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