Article
Genetic polymorphism of metallothionein 2A and risk of laryngeal cancer in a Polish population.
Medical oncology (Northwood, London, England) - 1 Jul 2014
Starska Katarzyna, Krześlak Anna, Forma Ewa, Olszewski Jurek, Lewy-Trenda Iwona, Osuch-Wójcikiewicz Ewa, Bryś Magdalena
Abstract excerpt
Metallothioneins are intracellular regulators of many biological mechanisms including differentiation, proliferation, angiogenesis and invasion, which are crucial processes in carcinogenesis. This study examines the association between three single-nucleotide polymorphisms at loci -5 A/G (rs28366003) and -209 A/G (rs1610216) in the core promoter region and at locus +838 C/G (rs10636) in 3'UTR region of the...
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