Article
Metallothionein 2A genetic polymorphisms and risk of ductal breast cancer.
Clinical and experimental medicine - 1 Feb 2014
Krześlak Anna, Forma Ewa, Jóźwiak Paweł, Szymczyk Agnieszka, Smolarz Beata, Romanowicz-Makowska Hanna, Różański Waldemar, Bryś Magdalena
Abstract excerpt
Metallothioneins (MTs) are a family of metal binding proteins that play an important role in cellular processes such as proliferation and apoptosis. Metallothionein 2A is the most expressed MT isoform in the breast cells. A number of studies have demonstrated increased MT2A expression in various human tumors, including breast cancer. We carried out an association study to examine whether MT2A gene polymorphisms...
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