Article
The -5 A/G single-nucleotide polymorphism in the core promoter region of MT2A and its effect on allele-specific gene expression and Cd, Zn and Cu levels in laryngeal cancer.
Toxicology and applied pharmacology - 15 Oct 2014
Starska Katarzyna, Krześlak Anna, Forma Ewa, Olszewski Jurek, Morawiec-Sztandera Alina, Aleksandrowicz Paweł, Lewy-Trenda Iwona, Bryś Magdalena
Abstract excerpt
Metallothioneins (MTs) are low molecular weight, cysteine-rich heavy metal-binding proteins which participate in the mechanisms of Zn homeostasis, and protect against toxic metals. MTs contain metal-thiolate cluster groups and suppress metal toxicity by binding to them. The aim of this study was to determine the -5 A/G (rs28366003) single-nucleotide polymorphism (SNP) in the core promoter region of the MT2A gene...
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