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Article

A polymorphism in JMJD2C alters the cleavage by caspase-3 and the prognosis of human breast cancer.

Oncotarget - 15 Jul 2014

Hong Qi, Yu Sanjian, Yang Yu, Liu Guangyu, Shao Zhiming

Abstract excerpt

JMJD2C is a candidate oncogene that encodes a histone lysine demethylase with the ability to demethylate the lysine 9 residue of histone H3 (H3K9). The expression levels of JMJD2C are associated with tumor development and clinical outcome. Here we identify JMJD2C as a new substrate for caspase-3. JMJD2C is cleaved by caspase-3 at DEVD396G motif and then loses its demethylase activity. Additionally, we uncover...

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Identifiers

PMID: 24952432
DOI: 10.18632/oncotarget.2029
PMCID: PMC4148098

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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