Efficacy of DNA double-strand breaks repair in breast cancer is decreased in carriers of the variant allele of the UBC9 gene c.73G>A polymorphism.

doi:10.1016/j.mrfmmm.2010.09.002

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Article

Efficacy of DNA double-strand breaks repair in breast cancer is decreased in carriers of the variant allele of the UBC9 gene c.73G>A polymorphism.

Mutation research - 10 Dec 2010

Synowiec Ewelina, Krupa Renata, Morawiec Zbigniew, Wasylecka Maja, Dziki Lukasz, Morawiec Jan, Blasiak Janusz, Wozniak Katarzyna

Abstract excerpt

UBC9 (E2) SUMO conjugating enzyme plays an important role in the maintenance of genome stability and integrity. In the present work we examined the association between the c.73G>A (Val25Met) polymorphism of the UBC9 gene (rs11553473) and efficacy of DNA double-strand breaks (DSBs) repair (DRE) in breast cancer patients. We determined the level of endogenous (basal) and exogenous (induced by γ-irradiation) DSBs...

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PMID: 20863840
DOI: 10.1016/j.mrfmmm.2010.09.002

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