Reduction in podocyte SIRT1 accelerates kidney injury in aging mice.

Abstract excerpt

Both the incidence and prevalence of chronic kidney disease are increasing in the elderly population. Although aging is known to induce kidney injury, the underlying molecular mechanisms remain unclear. Sirtuin 1 (Sirt1), a longevity gene, is known to protect kidney cell injury from various cellular stresses. In previous studies, we showed that the podocyte-specific loss of Sirt1 aggravates diabetic kidney...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to 8-Hydroxy-2'-Deoxyguanosine
• Share to Deoxyguanosine