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Article

Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling

29 Aug 2017

Abstract excerpt

Podocyte injury is a major determinant of proteinuric kidney disease and the identification of potential therapeutic targets for preventing podocyte injury has clinical importance. Here, we show that histone deacetylase Sirt6 protects against podocyte injury through epigenetic regulation of Notch signaling. Sirt6 is downregulated in renal biopsies from patients with podocytopathies and its expression correlates...

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PMID: 28871079
DOI: 10.1038/s41467-017-00498-4

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