Article
Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes.
Nature communications - 22 Jan 2018
Bonàs-Guarch Sílvia, Guindo-Martínez Marta, Miguel-Escalada Irene, Grarup Niels, Sebastian David, Rodriguez-Fos Elias, Sánchez Friman, Planas-Fèlix Mercè, Cortes-Sánchez Paula, González Santi, Timshel Pascal, Pers Tune H, Morgan Claire C, Moran Ignasi, Atla Goutham, González Juan R, Puiggros Montserrat, Martí Jonathan, Andersson Ehm A, Díaz Carlos, Badia Rosa M, Udler Miriam, Leong Aaron, Kaur Varindepal, Flannick Jason, Jørgensen Torben, Linneberg Allan, Jørgensen Marit E, Witte Daniel R, Christensen Cramer, Brandslund Ivan, Appel Emil V, Scott Robert A, Luan Jian'an, Langenberg Claudia, Wareham Nicholas J, Pedersen Oluf, Zorzano Antonio, Florez Jose C, Hansen Torben, Ferrer Jorge, Mercader Josep Maria, Torrents David
Abstract excerpt
The reanalysis of existing GWAS data represents a powerful and cost-effective opportunity to gain insights into the genetics of complex diseases. By reanalyzing publicly available type 2 diabetes (T2D) genome-wide association studies (GWAS) data for 70,127 subjects, we identify seven novel associated regions, five driven by common variants (LYPLAL1, NEUROG3, CAMKK2, ABO, and GIP genes), one by a low-frequency...
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