Article
Macrophage migration inhibitory factor (MIF) -173 polymorphism is associated with clinical erythema nodosum in Löfgren's syndrome.
Cytokine - 1 Oct 2014
Karakaya B, van Moorsel C H M, van der Helm-van Mil A H M, Huizinga T W J, Ruven H J T, van der Vis J J, Grutters J C
Abstract excerpt
INTRODUCTION: Macrophage migration inhibitory factor (MIF) has been shown to be a key regulator in innate and adaptive immune responses. A single nucleotide polymorphism in the 5' region of the MIF gene, MIF -173∗G/C, is associated with increased MIF protein production, in vivo and in vitro. Associations have been shown between the minor MIF -173C allele and sarcoidosis patients with erythema nodosum (EN)....
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