Article
Association of MIF promoter polymorphisms with psoriasis in a Han population in northeastern China.
Journal of dermatological science - 1 Mar 2009
Wu Jie, Chen Feng, Zhang Xuelong, Li Yuzhen, Ma Hongyu, Zhou Yucheng, Jin Yan, Wang Haikuan, Bai Jing, Zhang Guiyin, Fu Songbin
Abstract excerpt
BACKGROUND: Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that plays an important part in the pathogenesis of autoimmune diseases. A high level of MIF has been detected in plaques of psoriasis and the sera of patients with psoriasis. Polymorphisms associated with autoimmune and inflammatory diseases exist in the promoter region of MIF and alter its expression. OBJECTIVE: The aim of...
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