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Article

Early selection of resistance-associated mutations in HIV-1 RT C-terminal domains across different subtypes: role of the genetic barrier to resistance.

The Journal of antimicrobial chemotherapy - 1 Oct 2014

Muniz Cláudia P, Soares Marcelo A, Santos André F

Abstract excerpt

OBJECTIVES: Interpretation of drug resistance mutation (DRM) has been based solely on HIV-1 subtype B. Reverse transcriptase (RT) C-terminal domains have been disregarded in resistance interpretation, as their clinical relevance is still controversial. We determined the emergence of DRM in RT C-terminal domains of different HIV-1 subtypes, the genetic barrier for the acquisition of these DRM and their temporal...

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Share to Anti-HIV Agents
Share to Drug Resistance, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to HIV Reverse Transcriptase

Share to Polymorphism, Genetic

Share to Protein Interaction Domains and Motifs

Share to Selection, Genetic

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Identifiers

PMID: 24948706
DOI: 10.1093/jac/dku214

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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