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Article

N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance.

PLoS medicine - 1 Dec 2007

Yap Soo-Huey, Sheen Chih-Wei, Fahey Jonathan, Zanin Mark, Tyssen David, Lima Viviane Dias, Wynhoven Brian, Kuiper Michael, Sluis-Cremer Nicolas, Harrigan P Richard, Tachedjian Gilda

Abstract excerpt

BACKGROUND: The catalytically active 66-kDa subunit of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) consists of DNA polymerase, connection, and ribonuclease H (RNase H) domains. Almost all known RT inhibitor resistance mutations identified to date map to the polymerase domain of the enzyme. However, the connection and RNase H domains are not routinely analysed in clinical samples and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18052601
DOI: 10.1371/journal.pmed.0040335
PMCID: PMC2100143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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