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Article

Hot-spot residues at the E9/Im9 interface help binding via different mechanisms.

Biopolymers - 1 Nov 2008

Wong Sergio E, Baron Riccardo, McCammon J Andrew

Abstract excerpt

Protein-protein association involves many interface interactions, but they do not contribute equally. Ala scanning experiments reveal that only a few mutations significantly lower binding affinity. These key residues, which appear to drive protein-protein association, are called hot-spot residues...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18546205
DOI: 10.1002/bip.21035
PMCID: PMC2575057

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18546205-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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