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Article

Rational design of faster associating and tighter binding protein complexes.

Nature structural biology - 1 Jul 2000

Selzer T, Albeck S, Schreiber G

Abstract excerpt

A protein design strategy was developed to specifically enhance the rate of association (k(on)) between a pair of proteins without affecting the rate of dissociation (k(off)). The method is based on increasing the electrostatic attraction between the proteins by incorporating charged residues in...

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Identifiers

PMID: 10876236
DOI: 10.1038/76744

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-10876236-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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