Article
Subphenotype meta-analysis of testicular cancer genome-wide association study data suggests a role for RBFOX family genes in cryptorchidism susceptibility.
Human reproduction (Oxford, England) - 1 May 2018
Wang Yanping, Gray Dione R, Robbins Alan K, Crowgey Erin L, Chanock Stephen J, Greene Mark H, McGlynn Katherine A, Nathanson Katherine, Turnbull Clare, Wang Zhaoming, Devoto Marcella, Barthold Julia Spencer
Abstract excerpt
STUDY QUESTION: Can subphenotype analysis of genome-wide association study (GWAS) data from subjects with testicular germ cell tumor (TGCT) provide insight into cryptorchidism (undescended testis, UDT) susceptibility? SUMMARY ANSWER: Suggestive intragenic GWAS signals common to UDT, TGCT case-case and TGCT case-control analyses occur in genes encoding RBFOX RNA-binding proteins (RBPs) and their neurodevelopmental...
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