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Article

MED12 overexpression is a frequent event in castration-resistant prostate cancer

17 Jun 2014

Abstract excerpt

In a recent effort to unravel the molecular basis of prostate cancer (PCa), Barbieri and colleagues using whole-exome sequencing identified a novel recurrently mutated gene, MED12, in 5.4% of primary PCa. MED12, encoding a subunit of the Mediator complex, is a transducer of Wnt/β-catenin signaling, linked to modulation of hedgehog signaling and to the regulation of transforming growth factor beta (TGFβ)-receptor...

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PMID: 24938407
DOI: 10.1530/erc-14-0171

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