Article

CREB5 reprograms nuclear interactions to promote resistance to androgen receptor targeting therapies

2021-08-18

Abstract excerpt

Metastatic castration resistant prostate cancers (mCRPC) are treated with therapies that antagonize the androgen receptor (AR). Nearly all patients develop resistance to AR-targeted therapies (ART). Our previous work identified CREB5 as an upregulated target gene in human mCRPC that promoted resistance to all clinically-approved ART. The mechanisms by which CREB5 promotes progression of mCRPC or other cancers rema...

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Literature Corpus work: c76daa4c-a788-536f-bff4-2064ee3a56fc
DOI: 10.1101/2021.08.18.456892

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