Article
JARID1B is a luminal lineage-driving oncogene in breast cancer.
Cancer cell - 16 Jun 2014
Yamamoto Shoji, Wu Zhenhua, Russnes Hege G, Takagi Shinji, Peluffo Guillermo, Vaske Charles, Zhao Xi, Moen Vollan Hans Kristian, Maruyama Reo, Ekram Muhammad B, Sun Hanfei, Kim Jee Hyun, Carver Kristopher, Zucca Mattia, Feng Jianxing, Almendro Vanessa, Bessarabova Marina, Rueda Oscar M, Nikolsky Yuri, Caldas Carlos, Liu X Shirley, Polyak Kornelia
Abstract excerpt
Recurrent mutations in histone-modifying enzymes imply key roles in tumorigenesis, yet their functional relevance is largely unknown. Here, we show that JARID1B, encoding a histone H3 lysine 4 (H3K4) demethylase, is frequently amplified and overexpressed in luminal breast tumors and a somatic mutation in a basal-like breast cancer results in the gain of unique chromatin binding and luminal expression and splicing...
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