Article

A Distinct Chromatin State Drives Therapeutic Resistance in Invasive Lobular Breast Cancer

2022-03-30

Abstract excerpt

Most invasive lobular breast cancers (ILC) are of the luminal A subtype and strongly hormone receptor positive. Yet, they are relatively resistant to tamoxifen and are associated with inferior long-term outcomes compared to invasive ductal cancers (IDC). In this study, we sought to gain mechanistic insights into these clinical findings that are not explained by the genetic landscape of ILC and to identify strategi...

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Literature Corpus work: 63ce521d-bce4-571d-b622-c54ee2531167
DOI: 10.1101/2022.03.29.486217

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