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A Distinct Chromatin State Drives Therapeutic Resistance in Invasive Lobular Breast Cancer

11 Aug 2022

Abstract excerpt

Most invasive lobular breast cancers (ILC) are of the luminal A subtype and are strongly hormone receptor-positive. Yet, ILC is relatively resistant to tamoxifen and associated with inferior long-term outcomes compared with invasive ductal cancers (IDC). In this study, we sought to gain mechanistic insights into these clinical findings that are not explained by the genetic landscape of ILC and to identify...

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PMID: 35950920
DOI: 10.1158/0008-5472.can-21-3186

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