Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Constitutive activity in gonadotropin receptors.

Advances in pharmacology (San Diego, Calif.) - 1 Jan 2014

Ulloa-Aguirre Alfredo, Reiter Eric, Bousfield George, Dias James A, Huhtaniemi Ilpo

Abstract excerpt

Constitutively active mutants (CAMs) of gonadotropin receptors are, in general, rare conditions. Luteinizing hormone-choriogonadotropin receptor (LHCGR) CAMs provoke the dramatic phenotype of familial gonadotropin-independent isosexual male-limited precocious puberty, whereas in females, there is not yet any identified phenotype. Only one isolated follicle-stimulating hormone receptor (FSHR) CAM (Asp567Gly) has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Design
Share to FSHR gene
Share to LHCGR gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Animal

Share to Mutation

Source

Identifiers

PMID: 24931192
DOI: 10.1016/B978-0-12-417197-8.00002-X

Genes

FSHR
LHCGR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Constitutive activity in gonadotropin receptors.PMID 24931192Read ↗

Gonadotropins and their receptors: coevolution, genetic variants, receptor imaging, and functional antagonistsSemantic proximity Read ↗

Genetic Models for the Study of Luteinizing Hormone Receptor FunctionSemantic proximity Read ↗

Mutations in the human gonadotropin-releasing hormone receptor: insights into receptor biology and function.Semantic proximity Read ↗

Glycoprotein G-protein Coupled Receptors in Disease: Luteinizing Hormone Receptors and Follicle Stimulating Hormone ReceptorsSemantic proximity Read ↗

Lessons from constitutively active mutants of G protein-coupled receptors.Semantic proximity Read ↗

Rescue of mutant gonadotropin-releasing hormone receptor function independent of cognate receptor activity.Semantic proximity Read ↗

A Unique Constitutively Activating Mutation in Third Transmembrane Helix of Luteinizing Hormone Receptor Causes Sporadic Male Gonadotropin-Independent Precocious Puberty<sup>1</sup>Semantic proximity Read ↗

Mutations of gonadotropins and gonadotropin receptors: elucidating the physiology and pathophysiology of pituitary-gonadal function.Semantic proximity Read ↗

Molecular pathophysiology and clinical manifestations of gonadotropin receptor defects.Semantic proximity Read ↗

Structural requirements for mutational lutropin/choriogonadotropin receptor activation.Semantic proximity Read ↗

Mutations in G protein-coupled receptors that impact receptor trafficking and reproductive function.Semantic proximity Read ↗

Activating mutations of the lutropin choriogonadotropin receptor in precocious puberty.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.