Molecular pathophysiology and clinical manifestations of gonadotropin receptor defects.

Abstract excerpt

The gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) bind specific receptors, members of the G protein-coupled receptor superfamily. Mutations of gonadotropin receptors are classified into activating (constitutively active or gain-of-function mutations) and inactivating (loss-of-function mutations). Activating mutations of the LH receptor have been described in familial and sporadic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gonads
• Share to Mutation