Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activating mutations of the lutropin choriogonadotropin receptor in precocious puberty.

Receptors & channels - 1 Jan 2002

Shenker Andrew

Abstract excerpt

The human receptor for lutropin and chorionic gonadotropin (LHR) is a member of the G-protein-coupled receptor superfamily and plays a key role in normal and abnormal reproductive physiology. Naturally occurring mutations of the LHR gene that lead to hormone-independent signaling are associated with abnormal Leydig cell growth and precocious puberty in boys. These mutations affect 13 different residues in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Cell Division
Share to Leydig Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Models, Molecular

Share to Molecular Sequence Data

Share to Puberty, Precocious

Share to Receptors, LH

Share to Second Messenger Systems

Source

Identifiers

PMID: 12408104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activating mutations of the lutropin choriogonadotropin receptor in precocious puberty.PMID 12408104Read ↗

Luteinizing hormone receptor mutations in disorders of sexual development and cancer.Semantic proximity Read ↗

Diseases associated with mutations of the human lutropin receptor.Semantic proximity Read ↗

Heterogeneity of activating mutations of the human luteinizing hormone receptor in male-limited precocious puberty.Semantic proximity Read ↗

A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty.Semantic proximity Read ↗

A novel mutation of the luteinizing hormone receptor gene causing male gonadotropin-independent precocious puberty.Semantic proximity Read ↗

A novel luteinizing hormone receptor mutation in a patient with familial male-limited precocious puberty: effect of the size of a critical amino acid on receptor activity.Semantic proximity Read ↗

Activating and inactivating mutations in LH receptors.Semantic proximity Read ↗

Genetic heterogeneity of constitutively activating mutations of the human luteinizing hormone receptor in familial male-limited precocious puberty.Semantic proximity Read ↗

Mutations affecting gonadotropin secretion and action.Semantic proximity Read ↗

Molecular genetic, biochemical, and clinical implications of gonadotropin receptor mutations.Semantic proximity Read ↗

A Unique Constitutively Activating Mutation in Third Transmembrane Helix of Luteinizing Hormone Receptor Causes Sporadic Male Gonadotropin-Independent Precocious Puberty<sup>1</sup>Semantic proximity Read ↗

Naturally occurring mutations of the luteinizing hormone receptor gene affecting reproduction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.