Molecular disease map of bone characterizing the postmenopausal osteoporosis phenotype.

doi:10.1002/jbmr.396

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Article

Molecular disease map of bone characterizing the postmenopausal osteoporosis phenotype.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Aug 2011

Jemtland Rune, Holden Marit, Reppe Sjur, Olstad Ole K, Reinholt Finn P, Gautvik Vigdis T, Refvem Hilde, Frigessi Arnoldo, Houston Brian, Gautvik Kaare M

Abstract excerpt

Genome-wide gene expressions in bone biopsies from patients with postmenopausal osteoporosis and healthy controls were profiled, to identify osteoporosis candidate genes. All osteoporotic patients (n = 27) in an unbiased cohort of Norwegian women presented with bone mineral density (BMD) T-scores of less than -2.5 SD and one or more confirmed low-energy fracture(s). A validation group (n = 18) had clinical and...