Article
Polyamine-binding protein PotD2 is required for stress tolerance and virulence in Actinobacillus pleuropneumoniae.
Antonie van Leeuwenhoek - 1 Dec 2017
Zhu Zhuang, Zhao Qin, Zhao Yu, Zhang Fei, Wen Xintian, Huang Xiaobo, Wen Yiping, Wu Rui, Yan Qigui, Huang Yong, Ma Xiaoping, Han Xinfeng, Cao Sanjie
Abstract excerpt
Actinobacillus pleuropneumoniae is the cause of porcine contagious pleuropneumonia, which is one of the most important respiratory diseases in swine and causes huge economic losses in the swine industry. PotD, a polyamine-binding protein, has been well characterised in many pathogens of humans and animals. In this study, a ΔpotD2 mutant of A. pleuropneumoniae strain MS71 (serovar 1) was constructed successfully...
Topics
- Actinobacillus pleuropneumoniae
- Adaptation, Biological
- Animals
- Bacterial Proteins
- Computational Biology
- Genetic Complementation Test
- Immune Sera
- Mice
- Mutation
- Recombinant Proteins