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Article

Tumor cell-induced macrophage senescence plays a pivotal role in tumor initiation followed by stable growth in immunocompetent condition.

Journal for immunotherapy of cancer - 1 Nov 2023

Wada Haruka, Otsuka Ryo, Germeraad Wilfred T V, Murata Tomoki, Kondo Toru, Seino Ken-Ichiro

Abstract excerpt

BACKGROUND: The cancer stem cell theory proposes that tumor formation in vivo is driven only by specific tumor-initiating cells having stemness; however, clinical trials conducted to test drugs that target the tumor stemness provided unsatisfactory results thus far. Recent studies showed clear involvement of immunity in tumors; however, the requirements of tumor-initiation followed by stable growth in...

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Identifiers

PMID: 37963635
DOI: 10.1136/jitc-2023-006677
PMCID: PMC10649871

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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