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Article

Histone deacetylase 8 regulates cortactin deacetylation and contraction in smooth muscle tissues.

American journal of physiology. Cell physiology - 1 Aug 2014

Li Jia, Chen Shu, Cleary Rachel A, Wang Ruping, Gannon Olivia J, Seto Edward, Tang Dale D

Abstract excerpt

Histone deacetylases (HDACs) are a family of enzymes that mediate nucleosomal histone deacetylation and gene expression. Some members of the HDAC family have also been implicated in nonhistone protein deacetylation, which modulates cell-cycle control, differentiation, and cell migration. However, the role of HDACs in smooth muscle contraction is largely unknown. Here, HDAC8 was localized both in the cytoplasm and...

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Identifiers

PMID: 24920679
DOI: 10.1152/ajpcell.00102.2014
PMCID: PMC4121581

Genes

HDAC8

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