Article
Role of histone deacetylases in regulation of phenotype of ovine newborn pulmonary arterial smooth muscle cells.
Cell proliferation - 1 Dec 2013
Yang Q, Dahl M J, Albertine K H, Ramchandran R, Sun M, Raj J U
Abstract excerpt
OBJECTIVE: Pulmonary arterial hypertension, characterized by pulmonary vascular remodelling and vasoconstriction, is associated with excessive proliferative changes in pulmonary vascular walls. However, the role of HDACs in the phenotypic alteration of pulmonary arterial smooth muscle cells (PASMC) is largely unknown. MATERIAL AND METHODS: Pulmonary arterial smooth muscle cells were isolated from newborn sheep....
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