Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Necroptosis in microglia contributes to neuroinflammation and retinal degeneration through TLR4 activation.

Cell death and differentiation - 1 Jan 2018

Huang Zijing, Zhou Tian, Sun Xiaowei, Zheng Yingfeng, Cheng Bing, Li Mei, Liu Xialin, He Chang

Abstract excerpt

Inflammation has emerged to be a critical mechanism responsible for neural damage and neurodegenerative diseases. Microglia, the resident innate immune cells in retina, are implicated as principal components of the immunological insult to retinal neural cells. The involvement of microglia in retinal inflammation is complex and here we propose for the first time that necroptosis in microglia triggers...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemokines
Share to Cytokines
Share to Microglia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Necrosis

Share to Oxidative Stress

Share to Receptor-Interacting Protein Serine-Threonine Kinases

Share to Retinal Degeneration

Share to Toll-Like Receptor 4

Source

Open in PubMed Open full text

Identifiers

PMID: 28885615
DOI: 10.1038/cdd.2017.141
PMCID: PMC5729519

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Necroptosis in microglia contributes to neuroinflammation and retinal degeneration through TLR4 activation.PMID 28885615Read ↗

RIP3-mediated microglial necroptosis promotes neuroinflammation and neurodegeneration in the early stages of diabetic retinopathySemantic proximity Read ↗

Targeting Necroptosis: A Novel Therapeutic Option for Retinal Degenerative DiseasesSemantic proximity Read ↗

IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative DiseasesSemantic proximity Read ↗

Reduced photoreceptor death and improved retinal function during retinal degeneration in mice lacking innate immunity adaptor protein MyD88.Semantic proximity Read ↗

Retinal Inflammation, Cell Death and Inherited Retinal DystrophiesSemantic proximity Read ↗

Immunological Landscape of Retinal Ischemia-Reperfusion Injury: Insights into Resident and Peripheral Immune Cell ResponsesSemantic proximity Read ↗

Retinal pigment epithelium-derived PD-L1 reprograms microglial cells and protects against retinal degeneration in mouse models of experimental AMD and genetic retinitis pigmentosaSemantic proximity Read ↗

Ibuprofen reduces inflammation, necroptosis and protects photoreceptors from light-induced retinal degenerationSemantic proximity Read ↗

Suppression of microglial activation is neuroprotective in a mouse model of human retinitis pigmentosa.Semantic proximity Read ↗

Systemic inflammation induced by lipopolysaccharide aggravates inherited retinal dystrophySemantic proximity Read ↗

The role of Toll-like receptors in retinal ischemic diseasesSemantic proximity Read ↗

Minocycline prevents the inflammatory response after retinal detachment, where microglia phenotypes being regulated through A20.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.