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Article

Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis.

eLife - 11 Jun 2014

Das Akash, Brown Michael S, Anderson Donald D, Goldstein Joseph L, Radhakrishnan Arun

Abstract excerpt

When human fibroblasts take up plasma low density lipoprotein (LDL), its cholesterol is liberated in lysosomes and eventually reaches the endoplasmic reticulum (ER) where it inhibits cholesterol synthesis by blocking activation of SREBPs. This feedback protects against cholesterol overaccumulation in the plasma membrane (PM). But how does ER know whether PM is saturated with cholesterol? In this study, we define...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24920391
DOI: 10.7554/eLife.02882
PMCID: PMC4086274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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