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Article

Impaired recycling of apolipoprotein E4 is associated with intracellular cholesterol accumulation.

The Journal of biological chemistry - 31 Dec 2004

Heeren Joerg, Grewal Thomas, Laatsch Alexander, Becker Nils, Rinninger Franz, Rye Kerry-Anne, Beisiegel Ulrike

Abstract excerpt

After internalization of triglyceride-rich lipoproteins (TRL) in hepatoma cells, TRL particles are immediately disintegrated in the early endosomal compartment. This involves the targeting of lipids and apoprotein B along the degradative pathway and the recycling of TRL-derived apoE through recycling endosomes. Re-secretion of apoE is accompanied by the concomitant association of apoE and cellular cholesterol...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15485881
DOI: 10.1074/jbc.M409324200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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