Article
A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus.
Nature communications - 12 Jun 2014
Cozen W, Timofeeva M N, Li D, Diepstra A, Hazelett D, Delahaye-Sourdeix M, Edlund C K, Franke L, Rostgaard K, Van Den Berg D J, Cortessis V K, Smedby K E, Glaser S L, Westra H-J, Robison L L, Mack T M, Ghesquieres H, Hwang A E, Nieters A, de Sanjose S, Lightfoot T, Becker N, Maynadie M, Foretova L, Roman E, Benavente Y, Rand K A, Nathwani B N, Glimelius B, Staines A, Boffetta P, Link B K, Kiemeney L, Ansell S M, Bhatia S, Strong L C, Galan P, Vatten L, Habermann T M, Duell E J, Lake A, Veenstra R N, Visser L, Liu Y, Urayama K Y, Montgomery D, Gaborieau V, Weiss L M, Byrnes G, Lathrop M, Cocco P, Best T, Skol A D, Adami H-O, Melbye M, Cerhan J R, Gallagher A, Taylor G M, Slager S L, Brennan P, Coetzee G A, Conti D V, Onel K, Jarrett R F, Hjalgrim H, van den Berg A, McKay J D
Abstract excerpt
Recent genome-wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. Here we perform a meta-analysis of three HL GWAS totaling 1,816 cases and 7,877 controls followed by replication in an independent set of 1,281 cases and 3,218 controls to find novel risk loci. We...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
