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Article

Determinants of the CmoB carboxymethyl transferase utilized for selective tRNA wobble modification.

Nucleic acids research - 19 May 2015

Kim Jungwook, Xiao Hui, Koh Junseock, Wang Yikai, Bonanno Jeffrey B, Thomas Keisha, Babbitt Patricia C, Brown Shoshana, Lee Young-Sam, Almo Steven C

Abstract excerpt

Enzyme-mediated modifications at the wobble position of tRNAs are essential for the translation of the genetic code. We report the genetic, biochemical and structural characterization of CmoB, the enzyme that recognizes the unique metabolite carboxy-S-adenosine-L-methionine (Cx-SAM) and catalyzes a carboxymethyl transfer reaction resulting in formation of 5-oxyacetyluridine at the wobble position of tRNAs. CmoB...

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PMID: 25855808
DOI: 10.1093/nar/gkv206
PMCID: PMC4482062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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