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Article

Comprehensive mutational scanning of a kinase in vivo reveals substrate-dependent fitness landscapes.

Nucleic acids research - 1 Aug 2014

Melnikov Alexandre, Rogov Peter, Wang Li, Gnirke Andreas, Mikkelsen Tarjei S

Abstract excerpt

Deep mutational scanning has emerged as a promising tool for mapping sequence-activity relationships in proteins, ribonucleic acid and deoxyribonucleic acid. In this approach, diverse variants of a sequence of interest are first ranked according to their activities in a relevant assay, and this ranking is then used to infer the shape of the fitness landscape around the wild-type sequence. Little is currently...

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Identifiers

PMID: 24914046
DOI: 10.1093/nar/gku511
PMCID: PMC4132701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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