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Article

PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors

27 May 2014

Abstract excerpt

The molecular mechanisms underlying the development of pancreatic neuroendocrine tumors (PanNETs) have not been well defined. We report here that the genomic region of the PHLDA3 gene undergoes loss of heterozygosity (LOH) at a remarkably high frequency in human PanNETs, and this genetic change is correlated with disease progression and poor prognosis. We also show that the PHLDA3 locus undergoes methylation in...

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PMID: 24912192
DOI: 10.1073/pnas.1319962111

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