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Article

p53-PHLDA3-Akt Network: The Key Regulators of Neuroendocrine Tumorigenesis.

International journal of molecular sciences - 8 Jun 2020

Chen Yu, Ohki Rieko

Abstract excerpt

p53 is a well-known tumor suppressor gene and one of the most extensively studied genes in cancer research. p53 functions largely as a transcription factor and can trigger a variety of antiproliferative programs via induction of its target genes. We identified PHLDA3 as a p53 target gene and found that its protein product is a suppressor of pancreatic neuroendocrine tumors (PanNETs) and a repressor of Akt...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32521808
DOI: 10.3390/ijms21114098
PMCID: PMC7312810

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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