Article

Recurrent loss of heterozygosity correlates with clinical outcome in pancreatic neuroendocrine cancer

2017-11-08

Abstract excerpt

Pancreatic neuroendocrine tumors (pNETs) are uncommon cancers arising from pancreatic islet cells. Analysis of gene mutation, copy number and RNA expression of 57 sporadic pNETs showed that pNET genomes are dominated by aneuploidy. Remarkably, ~25% of pNETs had genomes characterized by recurrent loss of heterozygosity (LoH) of the same 10 chromosomes, accompanied by bi-allelic MEN1 inactivation, and these cases h...

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Literature Corpus work: 0e691c95-4212-58bb-967a-4bc349fd9ca3
DOI: 10.1101/214585

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