Article
DNA methylation patterns identify subgroups of pancreatic neuroendocrine tumors with clinical association.
Communications biology - 3 Feb 2021
Lakis Vanessa, Lawlor Rita T, Newell Felicity, Patch Ann-Marie, Mafficini Andrea, Sadanandam Anguraj, Koufariotis Lambros T, Johnston Rebecca L, Leonard Conrad, Wood Scott, Rusev Borislav, Corbo Vincenzo, Luchini Claudio, Cingarlini Sara, Landoni Luca, Salvia Roberto, Milella Michele, Chang David, Bailey Peter, Jamieson Nigel B, Duthie Fraser, Gingras Marie-Claude, Muzny Donna M, Wheeler David A, Gibbs Richard A, Milione Massimo, Pederzoli Paolo, Samra Jaswinder S, Gill Anthony J, Johns Amber L, Pearson John V, Biankin Andrew V, Grimmond Sean M, Waddell Nicola, Nones Katia, Scarpa Aldo
Abstract excerpt
Here we report the DNA methylation profile of 84 sporadic pancreatic neuroendocrine tumors (PanNETs) with associated clinical and genomic information. We identified three subgroups of PanNETs, termed T1, T2 and T3, with distinct patterns of methylation. The T1 subgroup was enriched for functional tumors and ATRX, DAXX and MEN1 wild-type genotypes. The T2 subgroup contained tumors with mutations in ATRX, DAXX and...
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