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Understanding the biology of HER3 receptor as a therapeutic target in human cancer

2 Jun 2018

Abstract excerpt

HER3 belongs to the human epidermal growth factor receptor (HER) family which also includes HER1/EGFR/erbB1, HER2/erbB2, and HER4/erbB4. As a unique member of the HER family, HER3 lacks or has little intrinsic tyrosine kinase activity. It frequently co-expresses and forms heterodimers with other receptor tyrosine kinases (RTKs) in cancer cells to activate oncogenic signaling, especially the PI-3K/Akt pathway and...

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PMID: 30109175
DOI: 10.1016/j.apsb.2018.05.010

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