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Article

Activation of ErbB3-PI3-kinase pathway is correlated with malignant phenotypes of adenocarcinomas.

Oncogene - 6 Mar 2003

Kobayashi Michimoto, Iwamatsu Akihiro, Shinohara-Kanda Azusa, Ihara Sayoko, Fukui Yasuhisa

Abstract excerpt

Signet-ring cell carcinomas are malignant dedifferentiated carcinomas, which are frequently found in the stomach. We previously demonstrated that a 200 kDa protein is often constitutively phosphorylated on tyrosine and bound to phosphatidylinositol 3-kinase (PI3-kinase) in signet-ring cell carcinoma cells. In this study, we purified the 200 kDa protein from an extract of NUGC-4 cells, a cell line of signet-ring...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Genes, erbB-2

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Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Source

Identifiers

PMID: 12618754
DOI: 10.1038/sj.onc.1206256

Genes

PI3
MUC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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