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Article

Regulation of ERBB3/HER3 signaling in cancer.

Oncotarget - 15 Nov 2014

Mujoo Kalpana, Choi Byung-Kwon, Huang Zhao, Zhang Ningyan, An Zhiqiang

Abstract excerpt

ERBB3/HER3 is emerging as a molecular target for various cancers. HER3 is overexpressed and activated in a number of cancer types under the conditions of acquired resistance to other HER family therapeutic interventions such as tyrosine kinase inhibitors and antibody therapies. Regulation of the HER3 expression and signaling involves numerous HER3 interacting proteins. These proteins include PI3K, Shc, and E3...

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Share to Carcinogenesis
Share to Colonic Neoplasms
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

Share to Molecular Targeted Therapy

Share to Receptor, ErbB-3

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Source

Open in PubMed Open full text

Identifiers

PMID: 25400118
DOI: 10.18632/oncotarget.2655
PMCID: PMC4279368

Genes

ERBB3
NEDD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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