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Article

Human cationic trypsinogen but not serine peptidase inhibitor, Kazal type 1 variants increase the risk of type 1 autoimmune pancreatitis.

Journal of gastroenterology and hepatology - 1 Dec 2014

Chang Ming-Chu, Jan I-Shiow, Liang Po-Chin, Jeng Yung-Ming, Yang Ching-Yao, Tien Yu-Wen, Wong Jau-Min, Chang Yu-Ting

Abstract excerpt

BACKGROUND AND AIM: Autoimmune pancreatitis (AIP) is a distinct disease entity. Whether the genes involved in pancreatic acinar cell injury, cationic trypsinogen gene (protease, serine, 1 [trypsin 1] [PRSS1]) and the pancreatic secretory trypsin inhibitor gene (serine peptidase inhibitor, Kazal type 1 [SPINK1]), are associated with AIP remains to be explored. METHODS: Genetic analyses of PRSS1 variants (exon 2...

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Autoimmune Diseases
Carrier Proteins
Exons
Genetic Variation
Pancreatitis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Trypsin Inhibitor, Kazal Pancreatic

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Identifiers

PMID: 24909264
DOI: 10.1111/jgh.12649

Genes

PRSS1
AIP
SPINK1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Human cationic trypsinogen but not serine peptidase inhibitor, Kazal type 1 variants increase the risk of type 1 autoimmune pancreatitis.PMID 24909264Read ↗

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